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Article

Genetic Variants in Caveolin-1 and RhoA/ROCK1 Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population.

PloS one - 1 Jan 2015

Zhao Ruizhe, Liu Kang, Huang Zhengkai, Wang Jun, Pan Yongsheng, Huang Yuan, Deng Xiaheng, Liu Jinliang, Qin Chao, Cheng Gong, Hua Lixin, Li Jie, Yin Changjun

Abstract excerpt

BACKGROUND: The RhoA/ROCK pathway and Caveolin-1 (Cav-1) participate in the process of tumorigenesis in numerous types of cancer. Up-regulation of RhoA/ROCK and Cav-1 expression is considered to be associated with the development and progression of clear cell renal cell carcinoma (ccRCC). We investigated the association between genetic variations of RhoA/ROCK and Cav-1 and the risk of ccRCC in the Chinese...

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Identifiers

PMID: 26066055
DOI: 10.1371/journal.pone.0128771
PMCID: PMC4467078

Genes

ROCK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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