Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular features that predict the response to antimetabolite chemotherapies

3 Oct 2017

Abstract excerpt

BACKGROUND: Antimetabolite chemotherapeutic agents that target cellular metabolism are widely used in the clinic and are thought to exert their anti-cancer effects mainly through non-specific cytotoxic effects. However, patients vary dramatically with respect to treatment outcome, and the sources of heterogeneity remain largely unknown. METHODS: Here, we introduce a computational method for identifying gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Colorectal Cancer Treatments and Studies
Share to Metabolomics and Mass Spectrometry Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29026541
DOI: 10.1186/s40170-017-0170-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular features that predict the response to antimetabolite chemotherapiesPMID 29026541Read ↗

Metabolic gene alterations impact the clinical aggressiveness and drug responses of 32 human cancers.Semantic proximity Read ↗

Identifying personalized metabolic signatures in breast cancerSemantic proximity Read ↗

The landscape of metabolic pathway dependencies in cancer cell linesSemantic proximity Read ↗

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.Semantic proximity Read ↗

Targeting Metabolic and Epigenetic Vulnerabilities in Glioblastoma with SN-38 and Rabusertib Combination TherapySemantic proximity Read ↗

Targeting Cellular Metabolism in Acute Myeloid Leukemia and The Role of Patient Heterogeneity.Semantic proximity Read ↗

Pan-cancer single-cell landscape of drug-metabolizing enzyme genesSemantic proximity Read ↗

Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer.Semantic proximity Read ↗

Multi-Omics Analysis of NCI-60 Cell Line Data Reveals Novel Metabolic Processes Linked with Resistance to Alkylating Anti-Cancer AgentsSemantic proximity Read ↗

Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics.Semantic proximity Read ↗

Metabolic profiling analysis of pharmacodynamic responses to chemotherapy in cancerSemantic proximity Read ↗

Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.