Article
Development of locus specific sub-clone separation by fluorescence in situ hybridization in suspension in chronic lymphocytic leukemia.
Cytometry. Part A : the journal of the International Society for Analytical Cytology - 1 Nov 2017
Do Cuc H, Bailey Sheree, Macardle Cindy, Thurgood Lauren A, Lower Karen M, Kuss Bryone J
Abstract excerpt
Intra-tumor genetic heterogeneity is a hallmark of cancer. The ability to monitor and analyze these sub-clonal cell populations can be considered key to successful treatment, particularly in the modern era of targeted therapies. Although advances in sequencing technologies have significantly improved our ability to analyze the mutational landscape of tumors, this utility is reduced when considering small, but...
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