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Article

MYCN contributes to the malignant characteristics of erythroleukemia through EZH2-mediated epigenetic repression of p21

12 Oct 2017

Abstract excerpt

MYC proto-oncogene family including c-myc and n-myc (MYCN) are critical for normal cell development and tumorigenesis. Overexpression of c-myc causes acute erythroleukemia in vivo. However, the role of MYCN in acute erythroleukemia remains poorly understood. In this study, we found that the patients with erythroleukemia showed higher expression of MYCN than normal controls. In vitro experiments, knockdown of MYCN...

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Identifiers

PMID: 29022893
DOI: 10.1038/cddis.2017.526

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