Correlation of EZH2 and related signaling molecules p-STAT3, p-ERK1/2, and MYC overexpression with H3K27 trimethylation associates differently to disease progression in JAK2 mutation -positive and -negative myeloid neoplasms.

Abstract excerpt

EZH2 is an important epigenetic regulator in malignant neoplasms. We investigated the tumorigenic roles of EZH2 and intracellular molecules in JAK2+/- myeloid neoplasms. EZH2 is upregulated in AML and non-leukemic myeloid neoplasms (M/N) and is associated with H3K27me3 co-expression. EZH2 overexpression is correlated with p-STAT3 and MYC upregulation in JAK2+ M/N, but only with MYC activation in JAK2- M/N. In...

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• Enhancer of Zeste Homolog 2 Protein
• Janus Kinase 2
• MAP Kinase Signaling System
• Mitogen-Activated Protein Kinase 1