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Article

Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo.

Gastroenterology - 1 Jan 2010

Arndt Stephanie, Maegdefrau Ulrike, Dorn Christoph, Schardt Katharina, Hellerbrand Claus, Bosserhoff Anja-Katrin

Abstract excerpt

BACKGROUND & AIMS: Recent studies identified bone morphogenic protein 6 (BMP6) as a key regulator of hepatic hepcidin expression and iron metabolism, but the cellular source of BMP6 and the reason for its specific effect on hepatocytes are unknown. METHODS: BMP and hepcidin expression upon iron sensing were analyzed in vivo in BMP6(-/-) and BMP6(+/+) mice and ex vivo in tissue and in vitro in cells of the liver...

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Source

Identifiers

PMID: 19786029
DOI: 10.1053/j.gastro.2009.09.048

Genes

BMP6
BMP2
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo.PMID 19786029Read ↗

Iron overload induces BMP6 expression in the liver but not in the duodenumSemantic proximity Read ↗

Bone morphogenetic proteins as regulators of iron metabolism.Semantic proximity Read ↗

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasisSemantic proximity Read ↗

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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6.Semantic proximity Read ↗

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge.Semantic proximity Read ↗

Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levelsSemantic proximity Read ↗

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Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin.Semantic proximity Read ↗

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.Semantic proximity Read ↗

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression.Semantic proximity Read ↗

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