A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

doi:10.1093/eurheartj/ehx467

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Article

A common missense variant of LILRB5 is associated with statin intolerance and myalgia.

European heart journal - 21 Dec 2017

K Siddiqui Moneeza, Maroteau Cyrielle, Veluchamy Abirami, Tornio Aleksi, Tavendale Roger, Carr Fiona, Abelega Ngu-Uma, Carr Dan, Bloch Katyrzyna, Hallberg Par, Yue Qun-Ying, Pearson Ewan R, Colhoun Helen M, Morris Andrew D, Dow Eleanor, George Jacob, Pirmohamed Munir, Ridker Paul M, Doney Alex S F, Alfirevic Ana, Wadelius Mia, Maitland-van der Zee Anke-Hilse, Chasman Daniel I, Palmer Colin N A

Abstract excerpt

Aims: A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. We examined the association of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29020356
DOI: 10.1093/eurheartj/ehx467
PMCID: PMC5837247

Genes

LILRB5

Provenance

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