The association of DNA variants at or near the IgH locus with rheumatoid arthritis.

doi:10.1111/j.1744-313x.1987.tb00380.x

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Article

The association of DNA variants at or near the IgH locus with rheumatoid arthritis.

Journal of immunogenetics - 1 Jan 2000

Sakkas L I, Demaine A G, Vaughan R W, Welsh K I, Panayi G S

Abstract excerpt

DNA samples from 78 patients with classical or definite rheumatoid arthritis (RA) and 132 healthy controls were analysed by the Southern blotting method, using two DNA probes: the first to the immunoglobulin mu heavy-chain switch region (S mu), in conjunction with the SstI restriction endonucleas...

Topics

Alleles
Arthritis, Rheumatoid
Chromosome Mapping
DNA
Female
HLA-DR Antigens
HLA-DR4 Antigen
Humans
Immunoglobulin Heavy Chains
Immunologic Techniques
Male
Phenotype
Polymorphism, Restriction Fragment Length

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