MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.

doi:10.1089/gtmb.2017.0124

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MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.

Genetic testing and molecular biomarkers - 1 Nov 2017

González-Mercado Mirna Gisel, Rivas Fernando, Gallegos-Arreola M Patricia, Morán-Moguel M Cristina, Salazar-Páramo Mario, González-López Laura, Gámez-Nava J Iván, Muñoz-Valle J Francisco, Medina-Coss Y León Ricardo, González-Mercado Anahí, Aceves Mario A, Dávalos Nory O, Macías-Chumacera Agustín, Dávalos Ingrid P

Abstract excerpt

AIM: To investigate the relationships of polymorphisms in genes whose protein products are related in the metabolic pathway of folic acid, particularly MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C, and disease activity in Mexican patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). MATERIALS AND METHODS: Sixty-eight patients with RA were included in the study who were being treated with...

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PMID: 28994615
DOI: 10.1089/gtmb.2017.0124
PMCID: PMC5695735

Genes

MTHFR
MTRR
RFC1

Variants

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