Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.

doi:10.1016/j.ejca.2017.08.033

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Article

Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Nov 2017

Suenaga Mitsukuni, Schirripa Marta, Cao Shu, Zhang Wu, Yang Dongyun, Dadduzio Vincenzo, Salvatore Lisa, Borelli Beatrice, Pietrantonio Filippo, Ning Yan, Okazaki Satoshi, Berger Martin D, Miyamoto Yuji, Gopez Roel, Barzi Afsaneh, Yamaguchi Toshiharu, Loupakis Fotios, Lenz Heinz-Josef

Abstract excerpt

BACKGROUND: Trifluridine (FTD) is an active cytotoxic component of the metastatic colorectal cancer (mCRC) drug TAS-102, and thymidine phosphorylase inhibitor (TPI) inhibits the rapid degradation of FTD. We tested whether single nucleotide polymorphisms (SNPs) in genes involved in FTD metabolism and TPI excretion could predict outcome in patients with mCRC treated with TAS-102. PATIENTS AND METHODS: We...

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PMID: 28992563
DOI: 10.1016/j.ejca.2017.08.033
PMCID: PMC7497848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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