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Pharmacogenomics and functional imaging to predict irinotecan pharmacokinetics and pharmacodynamics: the predict IR study.

Cancer chemotherapy and pharmacology - 1 Jul 2021

Michael Michael, Liauw Winston, McLachlan Sue-Anne, Link Emma, Matera Annetta, Thompson Michael, Jefford Michael, Hicks Rod J, Cullinane Carleen, Hatzimihalis Athena, Campbell Ian G, Rowley Simone, Beale Phillip J, Karapetis Christos S, Price Timothy, Burge Mathew E

Abstract excerpt

PURPOSE: Irinotecan (IR) displays significant PK/PD variability. This study evaluated functional hepatic imaging (HNI) and extensive pharmacogenomics (PGs) to explore associations with IR PK and PD (toxicity and response). METHODS: Eligible patients (pts) suitable for Irinotecan-based therapy. At baseline: (i) PGs: blood analyzed by the Affymetrix-DMET™-Plus-Array (1936 variants: 1931 single nucleotide...

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PMID: 33755789
DOI: 10.1007/s00280-021-04264-8

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