Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes

10 Oct 2017

Abstract excerpt

The members of the miR-17-92 cluster are upregulated in various cancers and function as a cluster of oncogenic miRNA. Our study characterized a new function of miR-17-5p, a member of the miR-17-92 cluster, in regulating cell proliferation in pancreatic cancer. Our results indicate that miR-17-5p was up-regulated in pancreatic adenocarcinoma and directly targeted the retinoblastoma-like protein 2 (RBL2), a tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28987387
DOI: 10.1016/j.canlet.2017.09.044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexesPMID 28987387Read ↗

KIF15 promotes pancreatic cancer proliferation via the MEK–ERK signalling pathwaySemantic proximity Read ↗

PD2/PAF1 at the Crossroads of the Cancer NetworkSemantic proximity Read ↗

Targeting the RB-pathway in Cancer TherapySemantic proximity Read ↗

LncRNA FAM225B Regulates PDIA4-Mediated Ovarian Cancer Cell Invasion and Migration via Modulating Transcription Factor DDX17Semantic proximity Read ↗

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transitionSemantic proximity Read ↗

Role of E2F in cell cycle control and cancerSemantic proximity Read ↗

CDK14/β-catenin/TCF4/miR-26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo.Semantic proximity Read ↗

The identification of novel targets of miR-16 and characterization of their biological functions in cancer cellsSemantic proximity Read ↗

The Role and Clinical Implications of the Retinoblastoma (RB)-E2F Pathway in Gastric CancerSemantic proximity Read ↗

Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phaseSemantic proximity Read ↗

The Rb/E2F pathway and cancerSemantic proximity Read ↗

miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.