Article
Familial Risk and a Genome-Wide Supported DRD2 Variant for Schizophrenia Predict Lateral Prefrontal-Amygdala Effective Connectivity During Emotion Processing.
Schizophrenia bulletin - 6 Jun 2018
Quarto Tiziana, Paparella Isabella, De Tullio Davide, Viscanti Giovanna, Fazio Leonardo, Taurisano Paolo, Romano Raffaella, Rampino Antonio, Masellis Rita, Popolizio Teresa, Selvaggi Pierluigi, Pergola Giulio, Bertolino Alessandro, Blasi Giuseppe
Abstract excerpt
The brain functional mechanisms translating genetic risk into emotional symptoms in schizophrenia (SCZ) may include abnormal functional integration between areas key for emotion processing, such as the amygdala and the lateral prefrontal cortex (LPFC). Indeed, investigation of these mechanisms is also complicated by emotion processing comprising different subcomponents and by disease-associated state variables....
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