Article
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.
Cancer research - 15 Sept 2006
Aleo Emanuela, Henderson Clare J, Fontanini Alessandra, Solazzo Barbara, Brancolini Claudio
Abstract excerpt
Identification of alternative pathways of caspase activation is an important step to develop new antitumor treatments. We report here the result of a screening with a small chemical library, the Developmental Therapeutics Program-National Cancer Institute "challenge set," on cells expressing mutated caspase-9. We have identified two molecules capable of activating an apoptosome-independent apoptotic pathway....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.