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Article

Short inverted repeats contribute to localized mutability in human somatic cells.

Nucleic acids research - 2 Nov 2017

Zou Xueqing, Morganella Sandro, Glodzik Dominik, Davies Helen, Li Yilin, Stratton Michael R, Nik-Zainal Serena

Abstract excerpt

Selected repetitive sequences termed short inverted repeats (SIRs) have the propensity to form secondary DNA structures called hairpins. SIRs comprise palindromic arm sequences separated by short spacer sequences that form the hairpin stem and loop respectively. Here, we show that SIRs confer an increase in localized mutability in breast cancer, which is domain-dependent with the greatest mutability observed...

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Identifiers

PMID: 28977645
DOI: 10.1093/nar/gkx731
PMCID: PMC5737083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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