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Article

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2017

Yu Emma P K, Reinhold Johannes, Yu Haixiang, Starks Lakshi, Uryga Anna K, Foote Kirsty, Finigan Alison, Figg Nichola, Pung Yuh-Fen, Logan Angela, Murphy Michael P, Bennett Martin

Abstract excerpt

OBJECTIVE: Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving mitochondrial respiration affects plaque burden or composition are unclear. We examined mitochondrial respiration in human atherosclerotic plaques and whether...

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Identifiers

PMID: 28970293
DOI: 10.1161/ATVBAHA.117.310042
PMCID: PMC5701734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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