CCR5Δ32 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes.

doi:10.1016/j.cyto.2017.09.022

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Article

CCR5Δ32 (rs333) polymorphism is associated with decreased risk of chronic and aggressive periodontitis: A case-control analysis based in disease resistance and susceptibility phenotypes.

Cytokine - 1 Mar 2018

Cavalla Franco, Biguetti Claudia C, Dionisio Thiago J, Azevedo Michelle C S, Martins Walter, Santos Carlos F, Trombone Ana Paula F, Silva Renato M, Letra Ariadne, Garlet Gustavo P

Abstract excerpt

Chronic and aggressive periodontitis are infectious diseases characterized by the irreversible destruction of periodontal tissues, which is mediated by the host inflammatory immune response triggered by periodontal infection. The chemokine receptor CCR5 play an important role in disease pathogenesis, contributing to pro-inflammatory response and osteoclastogenesis. CCR5Δ32 (rs333) is a loss-of-function mutation...

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PMID: 28969941
DOI: 10.1016/j.cyto.2017.09.022

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CCR5

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