Article
The use of chronic gingivitis as reference status increases the power and odds of periodontitis genetic studies: a proposal based in the exposure concept and clearer resistance and susceptibility phenotypes definition.
Journal of clinical periodontology - 1 Apr 2012
Garlet Gustavo Pompermaier, Trombone Ana Paula Favaro, Menezes Renato, Letra Ariadne, Repeke Carlos Eduardo, Vieira Andreia Espindola, Martins Walter, Neves Lucimara Teixeira das, Campanelli Ana Paula, Santos Carlos Ferreira Dos, Vieira Alexandre R
Abstract excerpt
AIM: Current literature on chronic periodontitis genetics encompasses numerous single nucleotide polymorphisms-focused case-control studies with inconsistent and controversial results, which typically disregards the exposure concept embraced by case-control definition. Herein, we propose a case-control design reappraisal by clear phenotype selection, where chronic gingivitis represents a genetically resistant...
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