Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease.

Epigenomics - 1 Nov 2017

Imm Jennifer, Kerrigan Talitha L, Jeffries Aaron, Lunnon Katie

Abstract excerpt

It is thought that both genetic and epigenetic variation play a role in Alzheimer's disease initiation and progression. With the advent of somatic cell reprogramming into induced pluripotent stem cells it is now possible to generate patient-derived cells that are able to more accurately model and recapitulate disease. Furthermore, by combining this with recent advances in (epi)genome editing technologies, it is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Epigenesis, Genetic
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Source

Identifiers

PMID: 28969469
DOI: 10.2217/epi-2017-0076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease.PMID 28969469Read ↗

Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment.Semantic proximity Read ↗

Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) riskSemantic proximity Read ↗

Advances in epigenetics and epigenomics for neurodegenerative diseases.Semantic proximity Read ↗

Epigenetic studies in Alzheimer's disease: current findings, caveats, and considerations for future studies.Semantic proximity Read ↗

Epigenome-wide association studies in Alzheimer's disease; achievements and challenges.Semantic proximity Read ↗

Applying gene-editing technology to elucidate the functional consequence of genetic and epigenetic variation in Alzheimer's disease.Semantic proximity Read ↗

Induced pluripotent stem cells as a discovery tool for Alzheimer׳s diseaseSemantic proximity Read ↗

Epigenetics in Alzheimer’s Disease: Perspective of DNA MethylationSemantic proximity Read ↗

Generation and characterization of human induced pluripotent stem cell (hiPSC) lines from an Alzheimer's disease (ASUi003-A) and non-demented control (ASUi004-A) patient homozygous for the Apolipoprotein e4 (APOE4) risk variant.Semantic proximity Read ↗

The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.Semantic proximity Read ↗

Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases.Semantic proximity Read ↗

Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived MicrogliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.