A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

doi:10.1371/journal.pone.0032327

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Article

A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.

PloS one - 1 Jan 2012

Froguel Philippe, Ndiaye Ndeye Coumba, Bonnefond Amélie, Bouatia-Naji Nabila, Dechaume Aurélie, Siest Gérard, Herbeth Bernard, Falchi Mario, Bottolo Leonardo, Guéant-Rodriguez Rosa-Maria, Lecoeur Cécile, Langlois Michel R, Labrune Yann, Ruokonen Aimo, El Shamieh Said, Stathopoulou Maria G, Morandi Anita, Maffeis Claudio, Meyre David, Delanghe Joris R, Jacobson Peter, Sjöström Lars, Carlsson Lena M S, Walley Andrew, Elliott Paul, Jarvelin Marjo-Riita, Dedoussis George V, Visvikis-Siest Sophie

Abstract excerpt

Haptoglobin is an acute phase inflammatory marker. Its main function is to bind hemoglobin released from erythrocytes to aid its elimination, and thereby haptoglobin prevents the generation of reactive oxygen species in the blood. Haptoglobin levels have been repeatedly associated with a variety of inflammation-linked infectious and non-infectious diseases, including malaria, tuberculosis, human immunodeficiency...

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PMID: 22403646
DOI: 10.1371/journal.pone.0032327
PMCID: PMC3293812

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