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Article

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

PloS one - 1 Jan 2017

Pilling Luke C, Atkins Janice L, Duff Michael O, Beaumont Robin N, Jones Samuel E, Tyrrell Jessica, Kuo Chia-Ling, Ruth Katherine S, Tuke Marcus A, Yaghootkar Hanieh, Wood Andrew R, Murray Anna, Weedon Michael N, Harries Lorna W, Kuchel George A, Ferrucci Luigi, Frayling Timothy M, Melzer David

Abstract excerpt

INTRODUCTION: Variability in red blood cell volumes (distribution width, RDW) increases with age and is strongly predictive of mortality, incident coronary heart disease and cancer. We investigated inherited genetic variation associated with RDW in 116,666 UK Biobank human volunteers. RESULTS: A large proportion RDW is explained by genetic variants (29%), especially in the older group (60+ year olds, 33.8%, <50...

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PMID: 28957414
DOI: 10.1371/journal.pone.0185083
PMCID: PMC5619771

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GAS6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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