Article

Acute high-dose irradiation of human primary ovarian cells reveals a shift in transcriptomics profile and impairment in cell-cell adhesion

2025-03-19

Abstract excerpt

<h4>STUDY QUESTION</h4> How do human cortical (cPOCs) and medullary (mPOCs) primary ovarian cells respond to acute X-ray exposure? <h4>SUMMARY ANSWER</h4> Acute high-dose X-ray exposure causes a shift in cPOCs and mPOCs transcriptomic profiles and impairs significantly their cell-cell adhesion ability. <h4>WHAT IS KNOWN ALREADY</h4> Radiotherapy is a leading cancer treatment, due to its effectiveness in targeti...

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Literature Corpus work: 3b1ce5d5-001b-5814-9e7b-1ef78339ba94
DOI: 10.1101/2025.03.19.644095

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