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Article

An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses.

PLoS pathogens - 1 Sept 2017

Hampe Irene A I, Friedman Justin, Edgerton Mira, Morschhäuser Joachim

Abstract excerpt

The opportunistic fungal pathogen Candida albicans frequently produces genetically altered variants to adapt to environmental changes and new host niches in the course of its life-long association with the human host. Gain-of-function mutations in zinc cluster transcription factors, which result in the constitutive upregulation of their target genes, are a common cause of acquired resistance to the widely used...

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Share to Antifungal Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Fungal

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Share to Gene Expression Regulation, Fungal

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 28953977
DOI: 10.1371/journal.ppat.1006655
PMCID: PMC5633205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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