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Article

Analysis of four neuroligin genes as candidates for autism.

European journal of human genetics : EJHG - 1 Dec 2005

Ylisaukko-oja Tero, Rehnström Karola, Auranen Mari, Vanhala Raija, Alen Reija, Kempas Elli, Ellonen Pekka, Turunen Joni A, Makkonen Ismo, Riikonen Raili, Nieminen-von Wendt Taina, von Wendt Lennart, Peltonen Leena, Järvelä Irma

Abstract excerpt

Neuroligins are cell-adhesion molecules located at the postsynaptic side of the synapse. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. Mutations in two X-linked neuroligin genes, NLGN3 and NLGN4, have recently been implicated in pathogenesis of autism. The neuroligin gene family consists of five members (NLGN1 at 3q26, NLGN2 at 17p13, NLGN3 at...

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Identifiers

PMID: 16077734
DOI: 10.1038/sj.ejhg.5201474

Genes

NLGN3
NLGN1
NLGN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of four neuroligin genes as candidates for autism.PMID 16077734Read ↗

Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands.Semantic proximity Read ↗

Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection.Semantic proximity Read ↗

Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients.Semantic proximity Read ↗

Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism.Semantic proximity Read ↗

Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort.Semantic proximity Read ↗

Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation.Semantic proximity Read ↗

Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.Semantic proximity Read ↗

Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients.Semantic proximity Read ↗

Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism.Semantic proximity Read ↗

X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family.Semantic proximity Read ↗

A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort.Semantic proximity Read ↗

Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies.Semantic proximity Read ↗

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