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Article

Differential DNA Hydroxymethylation in Human Uterine Leiomyoma Cells Depending on the Phase of Menstrual Cycle and Presence of MED12 Gene Mutations.

Bulletin of experimental biology and medicine - 1 Sept 2017

Kol'tsova A S, Pendina A A, Efimova O A, Kaminskaya A N, Tikhonov A V, Osinovskaya N S, Sultanov I Yu, Shved N Yu, Kakhiani M I, Baranov V S

Abstract excerpt

Using immunofluorescence with specific antibodies, we analyzed DNA hydroxymethylation in uncultured cells from 25 human uterine leiomyomas considering the menstrual cycle phase during surgery and the presence of MED12 gene mutations. It was found that each tumor node had specific DNA hydroxymethylation level that did not depend on the presence of mutations in MED12 gene, but depended on the phase of menstrual...

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Identifiers

PMID: 28944423
DOI: 10.1007/s10517-017-3870-3

Genes

MED12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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