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Article

High levels of Tryptophan reduce cell wall or membrane stress tolerance in Saccharomyces cerevisiae.

Bioscience, biotechnology, and biochemistry - 22 Sept 2021

Ohashi Kazuto, Chaleckis Romanas

Abstract excerpt

Tryptophan (Trp) is a proteinogenic aromatic amino acid; however, high levels of Trp are toxic in animals and yeast with unknown mechanisms. Previously, we suggested that aromatic aminotransferase Aro9 is important for excess Trp degradation. Besides, Schroeder and Ikui showed that aro9Δ is sensitive to membrane stress by sodium dodecyl sulfate. Therefore, Trp accumulation may reduce the cell wall or membrane...

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Source

Identifiers

PMID: 34387321
DOI: 10.1093/bbb/zbab142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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