Article
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin.
Molecular ecology - 1 May 2024
Bodawatta Kasun H, Hu Haofu, Schalk Felix, Daniel Jan-Martin, Maiah Gibson, Koane Bonny, Iova Bulisa, Beemelmanns Christine, Poulsen Michael, Jønsson Knud A
Abstract excerpt
Toxicity has evolved multiple times across the tree of life and serves important functions related to hunting, defence and parasite deterrence. Toxins are produced either in situ by the toxic organism itself or associated symbionts, or acquired through diet. The ability to exploit toxins from external sources requires adaptations that prevent toxic effects on the consumer (autoresistance). Here, we examine...
Topics
- Animals
- Batrachotoxins
- NAV1.4 Voltage-Gated Sodium Channel
- Mutation
- Molecular Docking Simulation
- Birds
- Selection, Genetic
- Neurotoxins