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Article

Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71.

Journal of biomedical science - 26 Apr 2014

Huang Sheng-Wen, Cheng Hui-Li, Hsieh Hsin-Yi, Chang Chia-Lun, Tsai Huey-Pin, Kuo Pin-Hwa, Wang Shih-Min, Liu Ching-Chuan, Su Ih-Jen, Wang Jen-Ren

Abstract excerpt

BACKGROUND: Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbreaks during 1998-2008 in Taiwan, genotype B5 was responsible for two large outbreaks in 2008 and 2012, respectively. In China, by contrast, EV71 often persists as a single genotype in the...

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Identifiers

PMID: 24766641
DOI: 10.1186/1423-0127-21-33
PMCID: PMC4021180

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