Article
Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and Chronic Diarrhea.
Inflammatory bowel diseases - 1 Dec 2017
Petersen Britt-Sabina, August Dietrich, Abt Renate, Alddafari Moudjahed, Atarod Lida, Baris Safa, Bhavsar Hemant, Brinkert Florian, Buchta Mary, Bulashevska Alla, Chee Ronnie, Cordeiro Ana I, Dara Naghi, Dückers Gregor, Elmarsafy Aisha, Frede Natalie, Galal Nermeen, Gerner Patrick, Glocker Erik-Oliver, Goldacker Sigune, Hammermann Jutta, Hasselblatt Peter, Havlicekova Zuzana, Hübscher Katrin, Jesenak Milos, Karaca Neslihan E, Karakoc-Aydiner Elif, Kharaghani Mahboubeh M, Kilic Sara S, Kiykim Ayca, Klein Christoph, Klemann Christian, Kobbe Robin, Kotlarz Daniel, Laass Martin W, Leahy T Ronan, Mesdaghi Mehrnaz, Mitton Sally, Neves João F, Öztürk Birol, Pereira Luis F, Rohr Jan, Restrepo Jessica L R, Ruzaike Gunda, Saleh Nadia, Seneviratne Suranjith, Senol Ebru, Speckmann Carsten, Tegtmeyer Daniel, Thankam Paul, van der Werff Ten Bosch Jutte, von Bernuth Horst, Zeissig Sebastian, Zeissig Yvonne, Franke Andre, Grimbacher Bodo
Abstract excerpt
BACKGROUND: In contrast to adult-onset inflammatory bowel disease (IBD), where many genetic loci have been shown to be involved in complex disease etiology, early-onset IBD (eoIBD) and associated syndromes can sometimes present as monogenic conditions. As a result, the clinical phenotype and ideal disease management in these patients often differ from those in adult-onset IBD. However, due to high costs and the...
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