Article
Immunomodulatory effects of bone marrow versus adipose tissue-derived mesenchymal stromal cells on NK cells: implications in the transplantation setting.
European journal of haematology - 1 Dec 2016
Blanco Belén, Herrero-Sánchez María Del Carmen, Rodríguez-Serrano Concepción, García-Martínez María Lourdes, Blanco Juan F, Muntión Sandra, García-Arranz Mariano, Sánchez-Guijo Fermín, Del Cañizo Consuelo
Abstract excerpt
INTRODUCTION: The ability of mesenchymal stromal cells (MSC) to suppress T-cell function has prompted their therapeutic use for graft-versus-host disease (GVHD) control. However, as MSC also modulate the activity of NK cells, which play an important role in graft-versus-leukemia (GVL) reaction, their administration could hamper this beneficial effect of allogeneic hematopoietic stem cell transplantation. MSC can...
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