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Article

Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity.

Cell communication and signaling : CCS - 30 Sept 2014

Chatterjee Debanjana, Marquardt Nicole, Tufa Dejene Milkessa, Beauclair Guillaume, Low Hui Zhi, Hatlapatka Tim, Hass Ralf, Kasper Cornelia, von Kaisenberg Constantin, Schmidt Reinhold Ernst, Jacobs Roland

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). In the early reconstitution phase following HSCT, natural killer (NK) cells represent the major lymphocyte population in peripheral blood and display graft-vs-leukemia (GvL) effects. The functional interactions between NK cells and MSCs have the...

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Identifiers

PMID: 25266361
DOI: 10.1186/s12964-014-0063-9
PMCID: PMC4195898

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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