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Article

Heme Oxygenase Activity and Heme Binding in a Neonatal Mouse Model.

Neonatology - 1 Jan 2017

Kourula Stephanie, Ang Joyce, Zhao Hui, Kalish Flora, Vandenabeele Peter, Sylvester Karl G, Wong Ronald J, Stevenson David K

Abstract excerpt

BACKGROUND: Severe hemolytic disease of the newborn leads to the release of pro-oxidative free heme (FH). Heme oxygenase (HO) is primarily responsible for detoxifying FH. OBJECTIVE: To investigate the protective effects of HO in a model of heme overload. METHODS: For in vitro studies, NIH3T3 HO-1-luc cells were incubated with 10, 30, or 60 µM FH or methemalbumin (MHA). HO-1 promoter activity was assessed 3, 6,...

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PMID: 28926834
DOI: 10.1159/000479493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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