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Article

Heme oxygenase-1 confers protection and alters T-cell populations in a mouse model of neonatal intestinal inflammation.

Pediatric research - 1 May 2015

Schulz Stephanie, Chisholm Karen M, Zhao Hui, Kalish Flora, Yang Yang, Wong Ronald J, Stevenson David K

Abstract excerpt

BACKGROUND: Necrotizing enterocolitis (NEC), an intestinal inflammatory disease affecting premature infants, is associated with low regulatory T (Treg) to effector T (Teff) cell ratios. We recently demonstrated that heme oxygenase-1 (HO-1) deficiency leads to increased NEC development. Here, we investigated the effects of HO-1 on T-cell proportions in a murine NEC-like injury model. METHODS: Intestinal injury was...

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Identifiers

PMID: 25665053
DOI: 10.1038/pr.2015.22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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