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Article

Some properties of three αB-crystallin mutants carrying point substitutions in the C-terminal domain and associated with congenital diseases.

Biochimie - 1 Nov 2017

Gerasimovich Evgeniia S, Strelkov Sergei V, Gusev Nikolai B

Abstract excerpt

Physico-chemical properties of G154S, R157H and A171T mutants of αB-crystallin (HspB5) associated with congenital human diseases including certain myopathies and cataract were investigated. Oligomers formed by G154S and A171T mutants have the size and apparent molecular weight indistinguishable from those of the wild-type HspB5, whereas the size of oligomers formed by R157H mutant is slightly smaller. All mutants...

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Identifiers

PMID: 28919577
DOI: 10.1016/j.biochi.2017.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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