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Article

MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma

8 Jul 2017

Abstract excerpt

Malignant pleural mesothelioma (MPM) is associated with an extremely poor prognosis, and most patients initially are or rapidly become unresponsive to platinum-based chemotherapy. MicroRNA-31 (miR-31) is encoded on a genomic fragile site, 9p21.3, which is reportedly lost in many MPM tumors. Based on previous findings in a variety of other cancers, we hypothesized that miR-31 alters chemosensitivity and that...

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PMID: 28918032
DOI: 10.1016/j.omtn.2017.07.001

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