Article
miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes.
Carcinogenesis - 1 May 2014
Hung Pei-Shih, Tu Hsi-Feng, Kao Shou-Yen, Yang Cheng-Chieh, Liu Chung-Ji, Huang Ting-Yun, Chang Kuo-Wei, Lin Shu-Chun
Abstract excerpt
Oral squamous cell carcinoma (OSCC) is a prevalent malignancy worldwide. MicroRNAs are short non-coding RNAs that regulate gene expression and are crucial for tumorigenesis. Previously, we have identified that miR-31 is frequently upregulated in OSCC and that this miR-31 increase, together with downstream effector modulation, enhances oral carcinogenesis. We have identified higher levels of miR-31 expression in...
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