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Article

Anemia in Patients With Resistance to Thyroid Hormone α: A Role for Thyroid Hormone Receptor α in Human Erythropoiesis.

The Journal of clinical endocrinology and metabolism - 1 Sept 2017

van Gucht Anja L M, Meima Marcel E, Moran Carla, Agostini Maura, Tylki-Szymanska Anna, Krajewska Malgorzata-Walasek, Chrzanowska Krystyna, Efthymiadou Alexandra, Chrysis Dionisios, Demir Korcan, Visser W Edward, Visser Theo J, Chatterjee Krishna, van Dijk Thamar B, Peeters Robin P

Abstract excerpt

Context: Patients with resistance to thyroid hormone (TH) α (RTHα) are characterized by growth retardation, macrocephaly, constipation, and abnormal thyroid function tests. In addition, almost all RTHα patients have mild anemia, the pathogenesis of which is unknown. Animal studies suggest an important role for TH and TH receptor (TR)α in erythropoiesis. Objective: To investigate whether a defect in TRα affects...

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Identifiers

PMID: 28911146
DOI: 10.1210/jc.2017-00840
PMCID: PMC5587074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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