Article
Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation.
Arthritis and rheumatism - 1 Aug 2001
Tak P P, Gerlag D M, Aupperle K R, van de Geest D A, Overbeek M, Bennett B L, Boyle D L, Manning A M, Firestein G S
Abstract excerpt
OBJECTIVE: Inhibitor of nuclear factor kappaB kinase beta (IkappaB kinase beta, or IKKbeta) has emerged as a key regulator of the transcription factor nuclear factor kappaB (NF-kappaB). Since IKKbeta could have both pro- and antiinflammatory activity, we examined whether its constitutive activation was sufficient to cause a chronic inflammatory disease such as rheumatoid arthritis. METHODS: Normal Lewis rats were...
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