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Article

Platelet-Targeted Delivery of Peripheral Blood Mononuclear Cells to the Ischemic Heart Restores Cardiac Function after Ischemia-Reperfusion Injury.

Theranostics - 1 Jan 2017

Ziegler Melanie, Wang Xiaowei, Lim Bock, Leitner Ephraem, Klingberg Franco, Ching Victoria, Yao Yu, Huang Dexing, Gao Xiao-Ming, Kiriazis Helen, Du Xiao-Jun, Haigh Jody J, Bobik Alex, Hagemeyer Christoph E, Ahrens Ingo, Peter Karlheinz

Abstract excerpt

One of the major hurdles in intravenous regenerative cell therapy is the low homing efficiency to the area where these cells are needed. To increase cell homing toward areas of myocardial damage, we developed a bispecific tandem single-chain antibody (Tand-scFvSca-1+GPIIb/IIIa) that binds with high affinity to activated platelets via the activated glycoprotein (GP)IIb/IIIa receptor, and to a subset of peripheral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myocardial Reperfusion Injury

Share to Neovascularization, Physiologic

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Source

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Identifiers

PMID: 28900504
DOI: 10.7150/thno.19698
PMCID: PMC5595126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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