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Article

IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation.

Scientific reports - 12 Sept 2017

Mitchell Ruth E, Hassan Masriana, Burton Bronwen R, Britton Graham, Hill Elaine V, Verhagen Johan, Wraith David C

Abstract excerpt

IL-10 is an immunomodulatory cytokine with a critical role in limiting inflammation in immune-mediated pathologies. The mechanisms leading to IL-10 expression by CD4+ T cells are being elucidated, with several cytokines implicated. We explored the effect of IL-4 on the natural phenomenon of IL-10 production by a chronically stimulated antigen-specific population of differentiated Th1 cells. In vitro, IL-4...

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Identifiers

PMID: 28900244
DOI: 10.1038/s41598-017-11803-y
PMCID: PMC5595963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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