Regulation of immune responses by T cells with different cytokine secretion phenotypes: role of a new cytokine, cytokine synthesis inhibitory factor (IL10).

Abstract excerpt

Subsets of T cells, defined by the patterns of cytokines that they secrete, show important functional differences, and appear to be at least partly responsible for the different immune responses induced by various pathogens. Two very distinct subsets, TH1 and TH2, are mutually inhibitory, and a newly discovered cytokine, IL10, is one of the mediators of this cross-regulation. IL10 inhibits the synthesis of...

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