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Lineage Switch Between B-Lymphoblastic Leukemia and Acute Myeloid Leukemia Intermediated by “Occult” Myelodysplastic Neoplasm

15 Mar 2017

Abstract excerpt

OBJECTIVES: Lineage switch occurs in rare leukemias, and the mechanism is unclear. We report two cases of B-lymphoblastic leukemia (B-ALL) relapsed as acute myeloid leukemia (AML). METHODS: Retrospective review of clinical and laboratory data. RESULTS: Complex cytogenetic abnormalities were detected in B-ALL for both cases with subclone heterogeneity. Postchemotherapy marrow biopsies showed trilineage...

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PMID: 28898985
DOI: 10.1093/ajcp/aqx055

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