Article
Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9-/- Mice.
Journal of dental research - 1 Oct 2017
Jia S, Zhou J, Wee Y, Mikkola M L, Schneider P, D'Souza R N
Abstract excerpt
To date, surgical interventions are the only means by which craniofacial anomalies can be corrected so that function, esthetics, and the sense of well-being are restored in affected individuals. Unfortunately, for patients with cleft palate-one of the most common of congenital birth defects-treatment following surgery is prolonged over a lifetime and often involves multidisciplinary regimens. Hence, there is a...
Topics
- Animals
- Antibodies, Monoclonal
- Cleft Palate
- Edar Receptor
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Mice
- Mice, Inbred Strains
- Morphogenesis
- PAX9 Transcription Factor
- Phenotype