Article
De novo activating epidermal growth factor mutations (EGFR) in small-cell lung cancer.
Internal medicine journal - 1 Sept 2017
Thai Alesha, Chia Puey L, Russell Prudence A, Do Hongdo, Dobrovic Alex, Mitchell Paul, John Thomas
Abstract excerpt
In Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non-small-cell lung cancer and are found with higher frequency in female, non-smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR mutations in patients with SCLC detected in tissue and in plasma cell free DNA, both of whom were...
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