Article
Identifying actionable variants using next generation sequencing in patients with a historical diagnosis of undifferentiated pleomorphic sarcoma.
International journal of cancer - 1 Jan 2018
Lewin Jeremy, Garg Swati, Lau Beatrice Y, Dickson Brendan C, Traub Frank, Gokgoz Nalan, Griffin Anthony M, Ferguson Peter C, Andrulis Irene L, Sim Hao-Wen, Kamel-Reid Suzanne, Stockley Tracy L, Siu Lillian L, Wunder Jay S, Razak Albiruni R A
Abstract excerpt
There are limited data regarding the molecular characterization of undifferentiated pleomorphic sarcomas (UPS; formerly malignant fibrous histiocytoma). This study aimed to investigate the utility of next generation sequencing (NGS) in UPS to identify subsets of patients who harbour actionable mutations. Patients diagnosed with UPS underwent pathological re-evaluation by a pathologist specializing in sarcoma....
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