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Article

Enteric Glia Regulate Gastrointestinal Motility but Are Not Required for Maintenance of the Epithelium in Mice.

Gastroenterology - 1 Oct 2017

Rao Meenakshi, Rastelli Daniella, Dong Lauren, Chiu Sophia, Setlik Wanda, Gershon Michael D, Corfas Gabriel

Abstract excerpt

BACKGROUND & AIMS: When the glial fibrillary acidic protein (GFAP) promoter is used to express cellular toxins that eliminate glia in mice, intestinal epithelial permeability and proliferation increase; this led to the concept that glia are required for maintenance of the gastrointestinal epithelium. Many enteric glia, however, particularly in the mucosa, do not express GFAP. In contrast, virtually all enteric...

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Source

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Identifiers

PMID: 28711628
DOI: 10.1053/j.gastro.2017.07.002
PMCID: PMC5623141

Genes

PLP1
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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