Article
Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis.
PloS one - 1 Jan 2017
Kwiecien Jacek M, Bassey-Archibong Blessing I, Dabrowski Wojciech, Rayner Lyndsay G, Lucas Alexandra R, Daniel Juliet M
Abstract excerpt
The metastatic activity of breast carcinomas results from complex genetic changes in epithelial tumor cells and accounts for 90% of deaths in affected patients. Although the invasion of the local lymphatic vessels and veins by malignant breast tumor cells and their subsequent metastasis to the lung, has been recognized, the mechanisms behind the metastatic activity of breast tumor cells to other distal organs and...
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