Article
Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression.
Nature medicine - 1 Aug 2006
Bandyopadhyay Sucharita, Zhan Rui, Chaudhuri Asok, Watabe Misako, Pai Sudha K, Hirota Shigeru, Hosobe Sadahiro, Tsukada Taisei, Miura Kunio, Takano Yukio, Saito Ken, Pauza Mary E, Hayashi Sunao, Wang Ying, Mohinta Sonia, Mashimo Tomoyuki, Iiizumi Megumi, Furuta Eiji, Watabe Kounosuke
Abstract excerpt
CD82, also known as KAI1, was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2 (ref. 1). The product of CD82 is KAI1, a 40- to 75-kDa tetraspanin cell-surface protein also known as the leukocyte cell-surface marker CD82 (refs. 1,2). Downregulation of KAI1 has been found to be clinically associated with metastatic progression in a variety of cancers, whereas...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.