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Article

Inhibition of E2F1 activity and cell cycle progression by arsenic via retinoblastoma protein

7 Sept 2017

Abstract excerpt

The regulation of cell cycle progression by steroid hormones and growth factors is important for maintaining normal cellular processes including development and cell proliferation. Deregulated progression through the G1/S and G2/M cell cycle transitions can lead to uncontrolled cell proliferation and cancer. The transcription factor E2F1, a key cell cycle regulator, targets genes encoding proteins that regulate...

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PMID: 28880708
DOI: 10.1080/15384101.2017.1338221

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