Article
Conformational mutations in human mitochondrial DNA.
Nature - 1 Jan 2000
Singh G, Neckelmann N, Wallace D C
Abstract excerpt
Variation in the human mitochondrial DNA (mtDNA) sequence has been extensively analysed using restriction fragment length polymorphisms (RFLPs). MtDNA RFLPs have previously been attributed to nucleotide changes within restriction endonuclease recognition sites or to small insertion-deletion mutations. We now report that RFLPs detected by polyacrylamide gel electrophoresis can also result from single nucleotide...
Topics
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA Restriction Enzymes
- DNA, Mitochondrial
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- Humans
- Mutation
- Nucleic Acid Conformation
- Polymorphism, Restriction Fragment Length