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Article

Conformational mutations in human mitochondrial DNA.

Nature - 1 Jan 2000

Singh G, Neckelmann N, Wallace D C

Abstract excerpt

Variation in the human mitochondrial DNA (mtDNA) sequence has been extensively analysed using restriction fragment length polymorphisms (RFLPs). MtDNA RFLPs have previously been attributed to nucleotide changes within restriction endonuclease recognition sites or to small insertion-deletion mutations. We now report that RFLPs detected by polyacrylamide gel electrophoresis can also result from single nucleotide...

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Share to Base Sequence
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Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Mitochondrial

Share to Electrophoresis, Polyacrylamide Gel

Share to Genetic Variation

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Share to Polymorphism, Restriction Fragment Length

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Identifiers

PMID: 2888022
DOI: 10.1038/329270a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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